Cantargia AB today announced that the IND application regarding the antibody CAN04 has been approved by the US FDA. CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development.

Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment.

I den USA-studie som Cantargia väntas starta senare i år kommer CAN04 kombineras med Keytruda. A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors (CANFOUR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Cantargia AB meddelade idag att en ansökan lämnats in kring en klinisk studie som undersöker antikroppen CAN04 i kombination med FOLFIRINOX för första linjens behandling av metastatisk bukspottkörtelcancer (PDAC).

BULL CANTARGIA X3 AVA 1. Forskningsbolaget Cantargia ansöker om att få starta en tredje parallell studie med antikroppen CAN04, denna gång i kombination med Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). The antibody CAN04 binds Cantargia. CANTA. NASDAQ Stockholm.

2020-3-10 · "Cantargia has focused the CAN04 development on solid tumors and the clinical data we have generated in patients with NSCLC or PDAC are encouraging. By acquiring this IP, we have secured all relevant IP on IL1RAP as a target for cancer therapy", said Göran Forsberg, CEO of Cantargia. For further information, please contact Göran Forsberg, CEO

Nidanilimab (CAN 04) is a humanised monoclonal antibody lacking fucose, being 10 Mar 2021 Cantargia files a clinical trial application with the regulatory Kempen & Co acted as Joint Bookrunner in Cantargia's SEK 564 million Capital Increase The main project, the antibody CAN04, is being studied clinically as 8 Apr 2020 Cantargia develops antibody-based pharmaceuticals against the interleukin 1 receptor accessory protein (IL1RAP). The antibody CAN04 binds 10 mar 2021 Cantargia AB meddelade idag att en ansökan lämnats in kring en klinisk studie som undersöker antikroppen CAN04 i kombination med About us.

”I slutändan kommer Novartis resultat att öka den totala datan och hjälpa Cantargia att definiera Can04:s positionering”, skriver Edison. Katalysatorer i närtid är utfallet från Novartis fas 3-studie Canopy-1 under andra halvåret 2021 och uppdaterade resultat från Cantargias fas 2a-studie Canfour senare i år.

It is developing two antibodies against IL1RAP, nidanilimab (CAN04) and CANxx. Nidanilimab is being studied in a Phase I/II CANFOUR in solid tumours focusing on NSCLC and pancreatic cancer. Exchange, Cantargia ansöker om start av ny klinisk studie kring antikroppen CAN04 och BULL CANTARGIA X2 AVA 1. 0.00. BULL CANTARGIA X3 AVA 1. Nidanilimab (CAN 04) is a humanised monoclonal antibody lacking fucose, being 10 Mar 2021 Cantargia files a clinical trial application with the regulatory Kempen & Co acted as Joint Bookrunner in Cantargia's SEK 564 million Capital Increase The main project, the antibody CAN04, is being studied clinically as 8 Apr 2020 Cantargia develops antibody-based pharmaceuticals against the interleukin 1 receptor accessory protein (IL1RAP). The antibody CAN04 binds 10 mar 2021 Cantargia AB meddelade idag att en ansökan lämnats in kring en klinisk studie som undersöker antikroppen CAN04 i kombination med About us.

Överföringen av GMP-produktionen till Patheon Biologics B.V ingår i bolagets långsiktiga strategi. Cantargia AB ("Cantargia") meddelade idag att nya prekliniska resultat, som stödjer kombination av den kliniskt studerade antikroppen CAN04 med platinabaserade cellgifter, kommer presenteras vid två posterpresentationer på 2020 Annual Meeting of the American Association for Cancer Research (AACR), den 22-24 juni. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP). Antikroppen CAN04 binder IL1RAP med hög affinitet och verkar både genom blockad av IL-1-signalering och s.k. Antibody-Dependent Cellular Cytotoxicity (ADCC). Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 i nivå med de resultat som den nya immunomodulerande antikroppen Keytruda (pembrolizumab, Merck) nyligen visat i en fas 2-studie (KEYNOTE-799) på 216 svårt sjuka NSCLC-patienter (icke operabelt stadium III).
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The antibody CAN04 binds IL1RAP with high affinity and its anti-tumor activity Cantargia is now in the process of broadening the development activities and the next step is a phase Ib trial investigating CAN04 in combination with the PD1 binding antibody pembrolizumab Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). The antibody CAN04 binds IL1RAP with high affinity and functions through both Cantargia develops antibody-based pharmaceuticals against IL1RAP. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 increases the efficacy of chemotherapy.

Cantargia AB meddelade idag att en ansökan för en ny klinisk prövning (IND) gällande CAN04 har skickats in till det amerikanska läkemedelsverket (FDA). CAN04 är en antikropp som är riktad mot interleukin 1 receptor accessory protein (IL1RAP). CAN04 undersöks för behandling av icke-småcellig lungcancer (NSCLC) och Cantargia AB meddelade idag uppdaterade interimsresultat från den pågående kliniska studien med antikroppen CAN04, som blockerar interleukin-1 receptor accessory protein (IL1RAP), i kombination med cellgifter vid behandling av icke-småcellig lungcancer (NSCLC).
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Cantargia har anlitat Carnegie Investment Bank AB (publ), Kempen & Co ”Under 2020 har arbetet med CAN04 signifikant framskridit och de

Listing a study does not mean it has been evaluated by the U.S. Federal Government. Cantargia AB meddelade idag att en ansökan lämnats in kring en klinisk studie som undersöker antikroppen CAN04 i kombination med FOLFIRINOX för första linjens behandling av metastatisk bukspottkörtelcancer (PDAC). Studien är designad att komplettera det pågående kliniska programmet och därmed bredda utvecklingen av CAN04.

Cantargia AB gav idag en uppdatering om framstegen i dess utvecklingsprojekt kring antikropparna CAN04 och CAN10 till följd av den pågående COVID-19-pandemin. Den initiala doseskaleringsfasen för CAN04 har avslutats för både icke-småcellig lungcancer (NSCLC) och bukspottkörtelcancer (PDAC).

Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC).

The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of interleukin-1 (IL-1) signaling. Cantargia develops antibody-based pharmaceuticals against IL1RAP. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC). Cantargia submits IND application for CAN04 Cantargia AB today announced that the application for a US IND regarding the antibody CAN04 has been submitted to the US FDA. 2021-03-10 (R) Cantargia submits application to start new clinical trial investigating antibody CAN04 and FOLFIRINOX in pancreatic can 2021-03-01 Cantargia provides business updates at investor conferences during March 2021 (R) = Regulatory press releases Cantargia develops antibody-based pharmaceuticals against IL1RAP.